Pair Name	Betulinic acid, Imatinib
Disease Info	[ICD-11: 2B33.2]	Chronic myeloid leukemia		Investigative
Gene Regulation	Up-regulation	Expression	ABL1	hsa25
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CDK1	hsa983
	Up-regulation	Acetylation	H3C14	hsa126961
	Up-regulation	Acetylation	H4C14	KEGG ID N.A.
	Down-regulation	Expression	HDAC3	hsa8841
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	RB1	hsa5925
In Vitro Model	K-562R	Blast phase chronic myelogenous leukemia	Homo sapiens (Human)	CVCL_5950
Result	Our findings demonstrated that HDAC3 is an essential factor in BCR-ABL1 kinase-independent IM resistance, and that BA in combination with IM may be a novel treatment strategy for overcoming IM resistance in CML.